Human Protein Wnt-5A, WNT5A ELISA Kit

SKU: E6012Hu

Size:96 Tests-1 Kit

Background:Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor (PubMed: 15735754). Mediates motility of melanoma cells (PubMed: 17426020). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity).

Research_area:Stem Cells

Applications:ELISA

Target_protein:WNT5A

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.024ng/mL

Detection range:0.05-20ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Protein Wnt-5A

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P41221

MASS(Da):42,339

GeneID:7474

Synonyms:Protein Wnt-5a;WNT 5A;WNT5A

Gene names:WNT5A

Standard solution:24ng/mL