Human Protein Inhibitor Of Activated STAT 4,PIAS4 ELISA KIT

SKU: E6476Hu

Size:96 Tests-1 Kit

Background:Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. {ECO:0000269|PubMed:12511558, ECO:0000269|PubMed:12631292, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:15831457, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:22508508}.

Research_area:

Applications:ELISA

Target_protein:PIAS4

Reactivity:Human

Assay type:Sandwich

Sensitivity:12.27ng/L

Detection range:20-7000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Protein Inhibitor Of Activated STAT 4

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8N2W9

MASS(Da):56504

GeneID:51588

Synonyms:PIAS4 PIASG

Gene names:PIAS4

Standard solution:8000ng/L