Human Presenilin 1, PS-1 ELISA Kit

SKU: E5908Hu

Size:96 Tests-1 Kit

Background:Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed: 15274632, PubMed: 10545183, PubMed: 10593990, PubMed: 10206644, PubMed: 10899933, PubMed: 10811883, PubMed: 12679784, PubMed: 12740439, PubMed: 25043039, PubMed: 26280335, PubMed: 30598546, PubMed: 30630874, PubMed: 28269784, PubMed: 20460383). Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed: 15274632, PubMed: 25043039, PubMed: 26280335, PubMed: 30598546, PubMed: 30630874). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed: 9738936, PubMed: 10593990, PubMed: 10899933, PubMed: 10811883). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed: 11953314). Under conditions of apoptosis or calcium influx, cleaves CDH1 (PubMed: 11953314). This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PubMed: 9738936, PubMed: 11953314). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (PubMed: 17428795, PubMed: 28269784). The holoprotein functions as a calcium-leak Channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis (PubMed: 25394380, PubMed: 16959576). Involved in the regulation of neurite outgrowth (PubMed: 15004326, PubMed: 20460383). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (By similarity).

Research_area:Neuroscience

Applications:ELISA

Target_protein:PSEN1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.027ng/mL

Detection range:0.05-20ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Presenilin 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P49768

MASS(Da):52,668

GeneID:5663

Synonyms:Presenilin-1;Presenilin-1 CTF subunit;Presenilin-1 CTF12;Presenilin-1 NTF subunit;Protein S182;PS-1;PS1-CTF12;PSEN 1;PSEN1;

Gene names:PSEN1

Standard solution:24ng/mL