Human Podocalyxin, PCX ELISA Kit

SKU: E1834Hu

Size:96 Tests-1 Kit

Background:Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.

Research_area:Others

Applications:ELISA

Target_protein:PODXL

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.02ng/ml

Detection range:0.05-15ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Podocalyxin

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O00592

MASS(Da):58,635

GeneID:5420

Synonyms:GCTM-2 antigen;Gp200;PC;PCLP-1;Podocalyxin;Podocalyxin-like protein 1;PODXL

Gene names:PODXL

Standard solution:16ng/ml