Human Peptidyl-prolyl Cis-Trans Isomerase D, CYCLOPHILIN-40 ELISA Kit

SKU: E6692Hu

Size:96 Tests-1 Kit

Background:PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:11350175, PubMed:20676357). Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. (Microbial infection) May be involved in hepatitis C virus (HCV) replication and release.

Research_area:Immunology

Applications:ELISA

Target_protein:Cyclophilin-40

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.013ng/ml

Detection range:0.05-15ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Peptidyl-prolyl Cis-trans Isomerase D

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q08752

MASS(Da):40,764

GeneID:5481

Synonyms:40 kDa peptidyl-prolyl cis-trans isomerase;Cyclophilin-40;Cyclophilin-related protein;CYP-40;CYPD;Peptidyl-prolyl cis-trans isomerase D;PPIase D;Rotamase D

Gene names:PPID

Standard solution:16ng/ml