Human Peptidyl Arginine Deiminase Type-2, PADI2 ELISA Kit

SKU: E6764Hu

Size:96 Tests-1 Kit

Background:Protein-arginine deiminase type-2 is an enzyme that in humans is encoded by the PADI2 gene. This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.

Research_area:Neuroscience; Signal Transduction; Epigenetics and Nuclear Signaling; Metabolism

Applications:ELISA

Target_protein:PADI2

Reactivity:Human

Assay type:Sandwich

Sensitivity:3.55ng/L

Detection range:7-1500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Peptidyl Arginine deiminase type-2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Y2J8

MASS(Da):75,564

GeneID:11240

Synonyms:PAD2;PAD-H19;PADI2;PDI2;Peptidylarginine deiminase II;Protein-arginine deiminase type II;Protein-arginine deiminase type-2

Gene names:PADI2

Standard solution:1600ng/L