Human Nucleotide-binding Oligomerization Domain-containing Protein 1, NOD1 ELISA Kit

SKU: E5805Hu

Size:96 Tests-1 Kit

Background:Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.

Research_area:Cell Biology

Applications:ELISA

Target_protein:NOD1

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.36ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Nucleotide-Binding Oligomerization Domain-Containing Protein 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Y239

MASS(Da):107,691

GeneID:10392

Synonyms:Caspase recruitment domain-containing protein 4;NOD 1;NOD1;Nucleotide-binding oligomerization domain-containing protein 1

Gene names:NOD1

Standard solution:2400ng/L