Human Nuclear Inhibitor of Protein Phosphatase 1, PPP1R8 ELISA Kit

SKU: E5794Hu

Size:96 Tests-1 Kit

Background:Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation. Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.

Research_area:Others

Applications:ELISA

Target_protein:PPP1R8

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.19ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Nuclear Inhibitor of Protein Phosphatase 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q12972

MASS(Da):38,479

GeneID:5511

Synonyms:ARD-1;NIPP-1;Nuclear inhibitor of protein phosphatase 1;PPP 1R8;PPP1R8;Protein phosphatase 1 regulatory inhibitor subunit 8 [Includes: Activator of RNA decay

Gene names:PPP1R8

Standard solution:4800ng/L