Human Nlr Family Member X1, NLRX1 ELISA Kit

SKU: E5781Hu

Size:96 Tests-1 Kit

Background:Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed:22749352). Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).

Research_area:Immunology

Applications:ELISA

Target_protein:NLRX1

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.47ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:NLR family member X1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q86UT6

MASS(Da):107,616

GeneID:79671

Synonyms:Caterpiller protein 11.3;CLR11.3;DLNB26;NLR family member X1;NLRX1;NOD26;NOD5;NOD9;Nucleotide-binding oligomerization domain protein 26;Nucleotide-binding oligomerization domain protein 5;Nucleotide-binding oligomerization domain protein 9

Gene names:NLRX1

Standard solution:3200ng/L