Human Ninein/Gsk3B Interacting Protein, NIN ELISA Kit

SKU: E3201Hu

Size:96 Tests-1 Kit

Background:A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets (PubMed: 27484798, PubMed: 25920809, PubMed: 16981698). The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively (PubMed: 27484798, PubMed: 16981698). Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B (PubMed: 25920809). During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (PubMed: 19830702).

Research_area:Cell Biology

Applications:ELISA

Target_protein:GSKIP

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.05ng/ml

Detection range:0.1-30ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Ninein/Gsk3B Interacting Protein

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9P0R6

MASS(Da):15,648

GeneID:51527

Synonyms:GSK3beta interaction protein;GSK3B-interacting protein;GSKIP

Gene names:GSKIP

Standard solution:32ng/ml