Human Nicastrin, NCSTN ELISA Kit

SKU: E6925Hu

Size:96 Tests-1 Kit

Background:Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed: 10993067, PubMed: 12679784, PubMed: 25043039, PubMed: 26280335, PubMed: 30598546, PubMed: 30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.

Research_area:Neuroscience

Applications:ELISA

Target_protein:NCSTN

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.28ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Nicastrin

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q92542

MASS(Da):78,411

GeneID:23385

Synonyms:NCSTN;Nicastrin

Gene names:NCSTN

Standard solution:3200ng/L