Human Neutrophil Elastase/ELA2/ELANE ELISA Kit PicoKine®

SKU: EK2064

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: ELANE

Specificity: Natural and recombinant human ELANE

Background: In humans, neutrophil elastase is encoded by the ELANE gene, which resides on chromosome 19. It is mapped to 19p13.3. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19.

Immunogen: Expression system for standard: NS0; Immunogen sequence: I30-H267

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Uniprot ID: P08246

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 1991

Protein Name: Neutrophil elastase

Gene Full Name: elastase, neutrophil expressed

Synonyms: Bone marrow serine protease; ELA2; ELANE; Elastase 2; elastase 2; neutrophil; GE; HLE; HNE; Human leukocyte elastase; Medullasin; NE; Neutrophil elastase; PMN E; PMN elastase