Human Myelin Basic Protein, MBP ELISA Kit

SKU: E1531Hu

Size:96 Tests-1 Kit

Background:The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.

Research_area:Neuroscience

Applications:ELISA

Target_protein:MBP

Reactivity:Human

Assay type:Sandwich

Sensitivity:32.27ng/L

Detection range:50-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Myelin Basic Protein

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P02686

MASS(Da):33,117

GeneID:4155

Synonyms:MBP;Myelin A1 protein;Myelin basic protein;Myelin membrane encephalitogenic protein

Gene names:MBP

Standard solution:8000ng/L