Human Methionyl Aminopeptidase 2, METAP2 ELISA Kit

SKU: E2382Hu

Size:96 Tests-1 Kit

Background:Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val Peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:METAP2

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.022ng/ml

Detection range:0.05-10ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Methionyl Aminopeptidase 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P50579

MASS(Da):52,892

GeneID:10988

Synonyms:Initiation factor 2-associated 67 kDa glycoprotein;MAP 2;METAP 2;METAP2;Methionine aminopeptidase 2;p67;p67eIF2;Peptidase M

Gene names:METAP2

Standard solution:12.8ng/ml