Human Mast Cell Chymase, CMA1 ELISA Kit

SKU: E5638Hu

Size:96 Tests-1 Kit

Background:Chymase is an enzyme that in humans is encoded by the CMA1 gene. This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases.

Research_area:Others

Applications:ELISA

Target_protein:Cma1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.032ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Mast Cell Chymase

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P23946

MASS(Da):27,325

GeneID:1215

Synonyms:Alpha-chymase;chymase;Cma1;CYH;Mast cell protease I;MCT1

Gene names:CMA1

Standard solution:24ng/ml