Human Low Density Lipoprotein Receptor Related Protein 1,LRP1 ELISA KIT

SKU: E2298Hu

Size:96 Tests-1 Kit

Background:Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed:11907044, PubMed:12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor (PubMed:26142438, PubMed:1702392). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:12888553). {ECO:0000250|UniProtKB:Q91ZX7, ECO:0000269|PubMed:11907044, ECO:0000269|PubMed:12713657, ECO:0000269|PubMed:12888553, ECO:0000269|PubMed:1702392, ECO:0000269|PubMed:26142438, ECO:0000269|PubMed:32296178}.; (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A. {ECO:0000269|PubMed:1618748}.

Research_area:

Applications:ELISA

Target_protein:LRP1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.019ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Low Density Lipoprotein Receptor Related Protein 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q07954

MASS(Da):504606

GeneID:4035

Synonyms:LRP1 A2MR APR

Gene names:LRP1

Standard solution:24ng/ml