Human Low Density Lipoprotein Receptor Adapter Protein 1, LDLRAP1 ELISA Kit

SKU: E5599Hu

Size:96 Tests-1 Kit

Background:Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:LDLRAP1

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.88ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Low density lipoprotein receptor adapter protein 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q5SW96

MASS(Da):33,885

GeneID:26119

Synonyms:ARH;ARH1;ARH2;Autosomal recessive hypercholesterolemia protein;FHCB1;FHCB2;FHCL4;LDLRAP1;Low density lipoprotein receptor adapter protein 1;

Gene names:LDLRAP1

Standard solution:2400ng/L