Human Kremen Protein 1, KREMEN1 ELISA Kit

SKU: E1160Hu

Size:96 Tests-1 Kit

Background:Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:KREMEN1

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.98ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Kremen protein 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q96MU8

MASS(Da):51,744

GeneID:83999

Synonyms:Dickkopf receptor;ECTD13;KREMEN;Kremen protein 1;KREMEN1;Kringle domain-containing transmembrane protein 1;Kringle-containing protein marking the eye and the nose;KRM1

Gene names:KREMEN1

Standard solution:4800ng/L