Human Kinesin-like Protein Kif14, KIF14 ELISA Kit

SKU: E2776Hu

Size:96 Tests-1 Kit

Background:Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:24784001, PubMed:16648480). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302).

Research_area:Tags & Cell Markers; Signal Transduction

Applications:ELISA

Target_protein:KIF14

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.58ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Kinesin-like protein KIF14

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q15058

MASS(Da):186,492

GeneID:9928

Synonyms:KIF14;Kinesin-like protein KIF14;MCPH20;MKS12

Gene names:KIF14

Standard solution:2400ng/L