Human Karyopherin Subunit Alpha 2,KPNA2 ELISA KIT

SKU: E7203Hu

Size:96 Tests-1 Kit

Background:Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Research_area:

Applications:ELISA

Target_protein:KPNA2

Reactivity:Human

Assay type:Sandwich

Sensitivity:13.03ng/L

Detection range:30-9000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Karyopherin Subunit Alpha 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P52292

MASS(Da):57862

GeneID:3838

Synonyms:KPNA2 RCH1 SRP1

Gene names:KPNA2

Standard solution:9600ng/L