Human Interleukin-27 Subunit Beta, EBI3 ELISA Kit

SKU: E5520Hu

Size:96 Tests-1 Kit

Background:Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.

Research_area:Immunology

Applications:ELISA

Target_protein:EBI3

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.64ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Interleukin-27 Subunit Beta

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q14213

MASS(Da):25,396

GeneID:10148

Synonyms:EBI 3;EBI3;EBV-induced gene 3 protein;Epstein-Barr virus-induced gene 3 protein;IL-27 subunit beta;IL-27B;Interleukin-27 subunit beta

Gene names:EBI3

Standard solution:2400ng/L