Human Integrin Alpha 4,ITGa4 ELISA KIT

SKU: E3900Hu

Size:96 Tests-1 Kit

Background:Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). {ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:25398877}.

Research_area:

Applications:ELISA

Target_protein:ITGA4

Reactivity:Human

Assay type:Sandwich

Sensitivity:8.45pg/ml

Detection range:18.75-1200pg/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Integrin Alpha 4

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P13612

MASS(Da):114900

GeneID:3676

Synonyms:ITGA4 CD49D

Gene names:ITGA4

Standard solution:2400pg/ml