Human Inositol Oxygenase, MIOX ELISA Kit

SKU: E5468Hu

Size:96 Tests-1 Kit

Background:Inositol oxygenase, also commonly referred to as myo-inositol oxygenase (MIOX), is a non-heme di-iron enzyme that oxidizes myo-inositol to glucuronic acid. The enzyme employs a unique four-electron transfer at its Fe(II)/Fe(III) coordination sites and the reaction proceeds through the direct binding of myo-inositol followed by attack of the iron center by diatomic oxygen. This enzyme is part of the only known pathway for the catabolism of inositol in humans[2] and is expressed primarily in the kidneys. Recent medical research regarding MIOX has focused on understanding its role in metabolic and kidney diseases such as diabetes, obesity and acute kidney injury. Industrially-focused engineering efforts are centered on improving MIOX activity in order to produce glucaric acid in heterologous hosts.

Research_area:Others

Applications:ELISA

Target_protein:MIOX

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.22ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Inositol oxygenase

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9UGB7

MASS(Da):33,010

GeneID:55586

Synonyms:Aldehyde reductase-like 6;ALDRL6;Inositol oxygenase;Kidney-specific protein 32;MI oxygenase;MIOX;Myo-inositol oxygenase;Renal-specific oxidoreductase

Gene names:MIOX

Standard solution:2560ng/L