Human IgG Receptor Fcrn Large Subunit P51, FCGRT ELISA Kit

SKU: E5450Hu

Size:96 Tests-1 Kit

Background:Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:7964511, PubMed:10933786). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation (PubMed:10998088). In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (PubMed:24469444, PubMed:28330995). (Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29.

Research_area:Others

Applications:ELISA

Target_protein:FCGRT

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.09ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:IgG receptor FcRn large subunit p51

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P55899

MASS(Da):39,743

GeneID:2217

Synonyms:alpha-chain;FCGRT;FCRN;IgG Fc fragment receptor transporter alpha chain;IgG receptor FcRn large subunit p51;Neonatal Fc receptor

Gene names:FCGRT

Standard solution:2560ng/L