Human Hypoxia-inducible Factor 3 Alpha, HIF-3A ELISA Kit

SKU: E4763Hu

Size:96 Tests-1 Kit

Background:Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression (PubMed: 11573933, PubMed: 16126907, PubMed: 19694616, PubMed: 20416395, PubMed: 21069422). Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. Plays a role in the development of the cardiorespiratory system. May also be involved in apoptosis (By similarity). [Isoform 2]: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. Also inhibits hypoxia-inducible ARNT-mediated gene expression. [Isoform 3]: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. [Isoform 4]: Attenuates the ability of transcription factor HIF1A and EPAS1/HIF2A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation (PubMed: 16126907, PubMed: 17998805, PubMed: 19694616, PubMed: 20416395). May act as a tumor suppressor and inhibits malignant cell transformation (PubMed: 17998805). [Isoform 5]: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation.

Research_area:Others

Applications:ELISA

Target_protein:HIF3A

Reactivity:Human

Assay type:Sandwich

Sensitivity:3.32ng/L

Detection range:6-1500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Hypoxia-Inducible Factor 3 Alpha

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Y2N7

MASS(Da):72,433

GeneID:64344

Synonyms:Basic-helix-loop-helix-PAS protein MOP7;bHLHe17;Class E basic helix-loop-helix protein 17;HIF3A;HIF3-alpha;HIF-3-alpha;HIF3-alpha-1;Hypoxia-inducible factor 3-alpha;Inhibitory PAS domain protein;IPAS;Member of PAS protein 7;PAS domain-containing protein 7

Gene names:HIF3A

Standard solution:1600ng/L