Human Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate, HGS ELISA Kit

SKU: E5393Hu

Size:96 Tests-1 Kit

Background:Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.

Research_area:Cell Biology; Signal Transduction

Applications:ELISA

Target_protein:HGS

Reactivity:Human

Assay type:Sandwich

Sensitivity:6.97ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Hepatocyte growth factor-regulated tyrosine kinase substrate

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O14964

MASS(Da):86,192

GeneID:9146

Synonyms:Hepatocyte growth factor-regulated tyrosine kinase substrate;HGS;HRS;Protein pp110

Gene names:HGS

Standard solution:3200ng/L