Human Granzyme A ELISA Kit PicoKine®

SKU: EK1162

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: GZMA

Specificity: Natural and recombinant human Granzyme A

Background: Granzyme A is a protein that in humans is encoded by the GZMA gene. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface nonself antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. GZMA induces caspase-independent apoptosis in a characteristic manner, except it causes a distinctive form of DNA damage: single-stranded DNA nicking. A target of GZMA is the SET complex, including HMGB2 and ANP32A.

Immunogen: Expression system for standard: NS0; Immunogen sequence: I29-V262

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Reference:

Uniprot ID: P12544

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 3001

Protein Name: Granzyme A

Gene Full Name: granzyme A

Synonyms: CTL tryptase; CTLA3; Fragmentin 1; GrA; Granzyme 1; Granzyme A; GZMA; H factor; Hanukkah factor; HF; HFSP