Human Glutamine Synthetase, GS ELISA Kit

SKU: E4569Hu

Size:96 Tests-1 Kit

Background:Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed: 30158707, PubMed: 16267323). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts (PubMed: 18662667). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PubMed: 30158707). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (PubMed: 30158707). Plays a role in ribosomal 40S subunit biogenesis (PubMed: 26711351).

Research_area:Neuroscience

Applications:ELISA

Target_protein:GLUL

Reactivity:Human

Assay type:Sandwich

Sensitivity:2.56ng/L

Detection range:5-1000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Glutamine Synthetase

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P15104

MASS(Da):42,064

GeneID:2752

Synonyms:GLUL;Glutamate--ammonia ligase;Glutamine synthetase;GS;Palmitoyltransferase GLUL

Gene names:GLUL

Standard solution:1280ng/L