Human General Transcription Factor Iih Subunit 1, GTF2H1 ELISA Kit

SKU: E2711Hu

Size:96 Tests-1 Kit

Background:Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:GTF2H1

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.54ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:General Transcription Factor Iih Subunit 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P32780

MASS(Da):62,032

GeneID:2965

Synonyms:Basic transcription factor 2 62 kDa subunit;BTF2 p62;General transcription factor IIH polypeptide 1;General transcription factor IIH subunit 1;GTF2H1;TFIIH basal transcription factor complex p62 subunit

Gene names:GTF2H1

Standard solution:2400ng/L