Human Gamma-aminobutyric Acid Receptor Subunit Alpha-1, GABRA1 ELISA Kit

SKU: E6503Hu

Size:96 Tests-1 Kit

Background:Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:23909897, PubMed:25489750, PubMed:29950725). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:23909897, PubMed:25489750). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (PubMed:23909897, PubMed:25489750). GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).

Research_area:Neuroscience

Applications:ELISA

Target_protein:GABRA1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.041ng/ml

Detection range:0.1-35ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Gamma-aminobutyric acid receptor subunit alpha-1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P14867

MASS(Da):51,802

GeneID:2554

Synonyms:DEE19;ECA4;EIEE19;EJM;EJM5;GABA(A receptor subunit alpha-1;GABRA1 ;Gamma-aminobutyric acid receptor subunit alpha-1

Gene names:GABRA1

Standard solution:40ng/ml