Human G Protein-coupled Receptor Kinase 6, GRK6 ELISA Kit

SKU: E5312Hu

Size:96 Tests-1 Kit

Background:Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:GRK6

Reactivity:Human

Assay type:Sandwich

Sensitivity:34.11ng/L

Detection range:70-15000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:G Protein-Coupled Receptor Kinase 6

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P43250

MASS(Da):65,991

GeneID:2870

Synonyms:G protein-coupled receptor kinase 6;G protein-coupled receptor kinase GRK6;GRK 6;GRK6

Gene names:GRK6

Standard solution:16000ng/L