Human Fructose-1, 6-Bisphosphatase 1, FBP1 ELISA Kit

SKU: E3183Hu

Size:96 Tests-1 Kit

Background:Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:FBP1

Reactivity:Human

Assay type:Sandwich

Sensitivity:3.54ng/ml

Detection range:7-1500ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Fructose-1, 6-Bisphosphatase 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P09467

MASS(Da):36,842

GeneID:2203

Synonyms:D-fructose-1,6-bisphosphate 1-phosphohydrolase 1;FBP 1;FBP1;FBPase 1;Fructose-1,6-bisphosphatase 1;Liver FBPase

Gene names:FBP1

Standard solution:1600ng/ml