Human Frizzled-7, FZD7 ELISA Kit

SKU: E2363Hu

Size:96 Tests-1 Kit

Background:Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by WNT8 induces expression of beta-catenin target genes (By similarity). Following ligand activation, binds to CCDC88C/DAPLE which displaces DVL1 from FZD7 and leads to inhibition of canonical Wnt signaling, activation of G-proteins by CCDC88C and triggering of non-canonical Wnt responses (PubMed:26126266). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium.

Research_area:Others

Applications:ELISA

Target_protein:FZD7

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.013ng/ml

Detection range:0.05-15ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Frizzled-7

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O75084

MASS(Da):63,620

GeneID:8324

Synonyms:Frizzled-7;Fz-7;FZD7;FzE3;hFz7

Gene names:FZD7

Standard solution:16ng/ml