Human FLT3/FLK2 ELISA Kit PicoKine®

SKU: EK0352

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: FLT3

Specificity: Natural and recombinant human FLT3/FLK2

Background: Cluster of differentiation antigen 135 (CD135) also known as fms like tyrosine kinase 3 (FLT-3), receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the FLT3 gene. It is mapped to 13q12.2. This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Immunogen: Expression system for standard: NS0; Immunogen sequence: N27-N541

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Reference:

Uniprot ID: P36888

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 2322

Protein Name: Receptor-type tyrosine-protein kinase FLT3

Gene Full Name: fms related receptor tyrosine kinase 3

Synonyms: CD135; FL cytokine receptor; FLK2; FLT 3; FLT3; Fms like tyrosine kinase 3; fms related tyrosine kinase 3; Stem cell tyrosine kinase 1; STK 1; STK1