Human FAS/Cd95 ELISA Kit PicoKine®

SKU: EK0335

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: FAS

Specificity: Natural and recombinant human sFAS

Background: Fas, also known as APO-1, CD95 and TNFRSF6, is a member of the nerve growth factor (NGF)/tumour necrosis factor (TNF) receptor superfamily and mediates apoptosis. The nucleotide sequence of the cDNAs reveales that the molecule coding for the Fas antigen determinant is a 319 amino acid polypeptide with a single transmembrane domain. The extracellular domain is rich in cysteine residue, and shows a similarity to that of human tumor necrosis factor receptors, human nerve growth factor receptor, and human B cell antigen CD40. The APO-1 antigen as defined by the mouse monoclonal antibody anti-APO-1 is previously found to be expressed on the cell surface of activated human T and B lymphocytes and a variety of malignant human lymphoid cell lines. The APO-1 antigen is found to be a membrane glycoprotein of 48-kDa. Fas antigen is expressed and functional on papillary thyroid cancer cells and this may have potential therapeutic significance. Fas can play a role as an inducer of both neurite growth in vitro and accelerates recovery after nerve injury in vivo. The FAS and FASL triggered apoptosis pathway plays an important role in human carcinogenesis.

Immunogen: Expression system for standard: NS0; Immunogen sequence: R17-N173

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Uniprot ID: P25445

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 355

Protein Name: Tumor necrosis factor receptor superfamily member 6

Gene Full Name: Fas cell surface death receptor

Synonyms: ALPS1A; APO 1; Apo 1 antigen; APT1; CD95; FAS; FAS/CD95; FAS1; FASLG receptor; FASTM; TNFRSF6