Human Eukaryotic Translation Initiation Factor 4E,EIF4E ELISA KIT

SKU: E7152Hu

Size:96 Tests-1 Kit

Background:Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:16271312, PubMed:22578813). In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (PubMed:24335285). Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap (By similarity). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (PubMed:24335285). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). {ECO:0000250|UniProtKB:P63073, ECO:0000250|UniProtKB:P63074, ECO:0000269|PubMed:16271312, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:24335285}.

Research_area:

Applications:ELISA

Target_protein:EIF4E

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.16ng/ml

Detection range:0.38-24ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Eukaryotic Translation Initiation Factor 4E

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P06730

MASS(Da):25097

GeneID:1977

Synonyms:EIF4E EIF4EL1 EIF4F

Gene names:EIF4E

Standard solution:48ng/ml