Human Epithelial Discoidin Domain-containing Receptor 1, DDR1 ELISA Kit

SKU: E5258Hu

Size:96 Tests-1 Kit

Background:Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the Matrix Metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.

Research_area:Others

Applications:ELISA

Target_protein:DDR1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.028ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Epithelial Discoidin Domain-Containing Receptor 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q08345

MASS(Da):101,128

GeneID:780

Synonyms:CD antigen CD167a;CD167 antigen-like family member A;Cell adhesion kinase;DDR 1;DDR1;Discoidin receptor tyrosine kinase;Epithelial discoidin domain receptor 1;Epithelial discoidin domain-containing receptor 1;HGK2;Mammary carcinoma kinase 10;MCK-10;Protein-tyrosine kinase 3A;Protein-tyrosine kinase RTK-6;TRK E;Tyrosine kinase DDR;Tyrosine-protein kinase CAK

Gene names:DDR1

Standard solution:24ng/ml