Human Endoplasmic Reticulum Aminopeptidase 1, ERAP1 ELISA Kit

SKU: E5237Hu

Size:96 Tests-1 Kit

Background:Aminopeptidase that plays a central role in Peptide trimming, a step required for the generation of most HLA class I-binding Peptides. Peptide trimming is essential to customize longer precursor Peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and Peptides with a hydrophobic C-terminus, while it has weak activity toward Peptides with charged C-terminus. May play a role in the inactivation of Peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.

Research_area:Immunology

Applications:ELISA

Target_protein:ERAP1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.024ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Endoplasmic Reticulum Aminopeptidase 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NZ08

MASS(Da):107,235

GeneID:51752

Synonyms:Adipocyte-derived leucine aminopeptidase;A-LAP;Aminopeptidase PILS;ARTS-1;Endoplasmic reticulum aminopeptidase 1;ERAP 1;ERAP1;PILS-AP;Puromycin-insensitive leucyl-specific aminopeptidase;Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator

Gene names:ERAP1

Standard solution:24ng/ml