Human E3 Ubiquitin-protein Ligase Trim63, TRIM63 ELISA Kit

SKU: E5218Hu

Size:96 Tests-1 Kit

Background:E3 ubiquitin-protein ligase TRIM63, also known as "MuRF1", is an enzyme that in humans is encoded by the TRIM63 gene. This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle.

Research_area:Cell Biology

Applications:ELISA

Target_protein:TRIM63

Reactivity:Human

Assay type:Sandwich

Sensitivity:3.13ng/L

Detection range:7-1500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:E3 ubiquitin-protein ligase TRIM63

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q969Q1

MASS(Da):40,248

GeneID:84676

Synonyms:E3 ubiquitin-protein ligase TRIM63;IRF;Iris RING finger protein;MURF1;MuRF-1;MURF2;Muscle-specific RING finger protein 1;RING finger protein 28;RING-type E3 ubiquitin transferase TRIM63;RNF28;SMRZ;Striated muscle RING zinc finger protein;TRIM63;Tripartite motif-containing protein 63

Gene names:TRIM63

Standard solution:1600ng/L