Human E2F Transcription Factor 1,E2F1 ELISA KIT

SKU: E7372Hu

Size:96 Tests-1 Kit

Background:Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Positively regulates transcription of RRP1B (PubMed:20040599). {ECO:0000250|UniProtKB:Q61501, ECO:0000269|PubMed:10675335, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:8170954}.

Research_area:

Applications:ELISA

Target_protein:E2F1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.11ng/ml

Detection range:0.2-70ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:E2F Transcription Factor 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q01094

MASS(Da):46920

GeneID:1869

Synonyms:E2F1 RBBP3

Gene names:E2F1

Standard solution:80ng/ml