Human Drosha Double Stranded RNA Specific Endoribonuclease,Drosha ELISA KIT

SKU: E4291hu

Size:96 Tests-1 Kit

Background:Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. {ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:14508493, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15565168, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}.

Research_area:

Applications:ELISA

Target_protein:DROSHA

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.045ng/ml

Detection range:0.1-30ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Drosha Double Stranded RNA Specific Endoribonuclease

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NRR4

MASS(Da):159316

GeneID:29102

Synonyms:DROSHA RN3 RNASE3L RNASEN

Gene names:DROSHA

Standard solution:40ng/ml