Human Disabled Homolog 1, DAB1 ELISA Kit

SKU: E2656Hu

Size:96 Tests-1 Kit

Background:The Disabled-1 (Dab1) gene encodes a key regulator of Reelin signaling. Reelin is a large glycoprotein secreted by neurons of the developing brain, particularly Cajal-Retzius cells. DAB1 functions downstream of Reln in a signaling pathway that controls cell positioning in the developing brain and during adult neurogenesis. It docks to the intracellular part of the Reelin very low density lipoprotein receptor (VLDLR) and apoE receptor type 2 (ApoER2) and becomes tyrosine-phosphorylated following binding of Reelin to cortical neurons. In mice, mutations of Dab1 and Reelin generate identical phenotypes. In humans, Reelin mutations are associated with brain malformations and mental retardation. In mice, Dab1 mutation results in the scrambler mouse phenotype.

Research_area:Others

Applications:ELISA

Target_protein:DAB1

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.36ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Disabled Homolog 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O75553

MASS(Da):63,775

GeneID:1600

Synonyms:DAB1;Disabled homolog 1;SCA37

Gene names:DAB1

Standard solution:3200ng/L