Human CXC-chemokine receptor 3,CXCR3 ELISA KIT

SKU: E0255Hu

Size:96 Tests-1 Kit

Background:[Isoform 1]: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. {ECO:0000269|PubMed:12782716}.; [Isoform 2]: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. {ECO:0000269|PubMed:12782716}.; [Isoform 3]: Mediates the activity of CXCL11.

Research_area:

Applications:ELISA

Target_protein:CXCR3

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.098ng/ml

Detection range:0.2-70ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:CXC-chemokine receptor 3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P49682

MASS(Da):40660

GeneID:2833

Synonyms:CXCR3 GPR9

Gene names:CXCR3

Standard solution:80ng/ml