Human Complement Factor H, CFH ELISA Kit

SKU: E0324Hu

Size:96 Tests-1 Kit

Background:Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces (PubMed: 21285368, PubMed: 25402769). Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop (PubMed: 19503104). As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b (PubMed: 18252712, PubMed: 28671664). In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed (PubMed: 9558116, PubMed: 20008295).

Research_area:Immunology

Applications:ELISA

Target_protein:CFH

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.88ng/ml

Detection range:10-3000ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Complement Factor H

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P08603

MASS(Da):139,096

GeneID:3075

Synonyms:CFH;Complement factor H;H factor 1

Gene names:CFH

Standard solution:3200ng/ml