Human Claudin 15, CLDN15 ELISA Kit

SKU: E2311Hu

Size:96 Tests-1 Kit

Background:Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na+, Li+ and K+ ions, but selects against Cl- ions. Plays an important role in paracellular Na+ transport in the intestine and in Na+ homeostasis. Required for normal Na+-dependent intestinal nutrient uptake.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:CLDN15

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.15ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Claudin 15

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P56746

MASS(Da):24,356

GeneID:24146

Synonyms:Claudin-15;CLDN15

Gene names:CLDN15

Standard solution:2400ng/L