Human Chymotrypsin-like Elastase Family Member 3B, CELA3B ELISA Kit

SKU: E6849Hu

Size:96 Tests-1 Kit

Background:Chymotrypsin-like elastase family member 3B also known as elastase-3B, protease E, or fecal elastase is an enzyme that in humans is encoded by the CELA3B gene. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.

Research_area:Signal Transduction; Cell Biology

Applications:ELISA

Target_protein:CELA3B

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.053ng/ml

Detection range:0.1-40ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Chymotrypsin-like elastase family member 3B

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P08861

MASS(Da):29,263

GeneID:23436

Synonyms:CBPP;CELA3B;Chymotrypsin-like elastase family member 3B;ELA3B;Elastase IIIB;Elastase-3B;Protease E

Gene names:CELA3B

Standard solution:48ng/ml