Human Cell Migration-inducing and Hyaluronan-binding Protein, CEMIP ELISA Kit

SKU: E5542Hu

Size:96 Tests-1 Kit

Background:Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.

Research_area:Others

Applications:ELISA

Target_protein:KIAA1199

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.026ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Cell migration-inducing and hyaluronan-binding protein

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8WUJ3

MASS(Da):152,998

GeneID:57214

Synonyms:CCSP1;Cell migration-inducing and hyaluronan-binding protein;HYBID;KIAA1199;TMEM2L

Gene names:CEMIP

Standard solution:24ng/ml