Human Cell Adhesion Molecule 1, CADM1 ELISA Kit

SKU: E5026Hu

Size:96 Tests-1 Kit

Background:Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner (PubMed: 22438059, PubMed: 12050160). Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner (By similarity). Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed: 15811952). In mast cells, may mediate attachment to and promote communication with nerves (PubMed: 15905536). CADM1, together with MITF, is essential for development and survival of mast cells in vivo (PubMed: 22438059). By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity). Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons (By similarity). May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (By similarity). Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells (PubMed: 11279526, PubMed: 12234973). May contribute to the less invasive phenotypes of lepidic growth tumor cells (PubMed: 12920246).

Research_area:Neuroscience

Applications:ELISA

Target_protein:CADM1

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.53ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Cell Adhesion Molecule 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9BY67

MASS(Da):48,509

GeneID:23705

Synonyms:CADM 1;CADM1;Cell adhesion molecule 1;IgSF4;Immunoglobulin superfamily member 4;NECL-2;Nectin-like protein 2;SgIgSF;Spermatogenic immunoglobulin superfamily;Synaptic cell adhesion molecule;SynCAM;TSLC-1;Tumor suppressor in lung cancer 1;

Gene names:CADM1

Standard solution:4800ng/L