Human Cartilage Oligomeric Matrix Protein, COMP ELISA Kit

SKU: E1486Hu

Size:96 Tests-1 Kit

Background:May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity).

Research_area:Cell Biology

Applications:ELISA

Target_protein:COMP

Reactivity:Human

Assay type:Sandwich

Sensitivity:15.66pg/ml

Detection range:30-9000pg/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Cartilage Oligomeric Matrix Protein

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P49747

MASS(Da):82,860

GeneID:1311

Synonyms:Cartilage oligomeric matrix protein;COMP;Thrombospondin-5;TSP5

Gene names:COMP

Standard solution:9600pg/ml