Human Canalicular multispecific organic anion transporter 2,ABCC3 ELISA KIT

SKU: E6591Hu

Size:96 Tests-1 Kit

Background:ATP-dependent transporter of the ATP-binding cassette (ABC) family that bind and hydrolyze ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:11581266, PubMed:15083066, PubMed:10359813). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:15083066, PubMed:11581266). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). Can confers resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:11581266, PubMed:10359813). {ECO:0000250|UniProtKB:O88563, ECO:0000269|PubMed:10359813, ECO:0000269|PubMed:11581266, ECO:0000269|PubMed:15083066}.

Research_area:

Applications:ELISA

Target_protein:ABCC3

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.69ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Canalicular multispecific organic anion transporter 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O15438

MASS(Da):169343

GeneID:8714

Synonyms:ABCC3 CMOAT2 MLP2 MRP3

Gene names:ABCC3

Standard solution:2400ng/L